The Na,K-ATPase receptor complex: its organization and membership.

نویسندگان

  • Sandrine V Pierre
  • Zijian Xie
چکیده

A major difference between the Na,K-ATPase ion pump and other P-type ATPases is its ability to bind cardiotonic steroids such as ouabain. Na,K-ATPase also interacts with many membrane and cytosolic proteins. In addition to their role in Na,K-ATPase regulation, it became apparent that some of the newly identified interactions are capable of organizing the Na,K-ATPase into various signaling complexes. This new function confers a ligand-like effect to cardiotonic steroids on cellular signal transduction. This article reviews these new developments and provides a comparison of Na,K-ATPase-mediated signal transduction with other receptors and ion transporters.

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عنوان ژورنال:
  • Cell biochemistry and biophysics

دوره 46 3  شماره 

صفحات  -

تاریخ انتشار 2006